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Several large clinical trials have demonstrated that GLP-1 receptor agonists can reduce the risk of cardiovascular events, such as heart attacks and strokes, in people with type 2 diabetes who are at high risk for heart disease

This is significant because it suggests that lower maintenance doses may be sufficient for some populations, particularly those using retatrutide for conditions other than maximum weight loss

Understanding how it compares helps put the side effect in context

Common Side Effects: Nausea, bloating, constipation, or occasional diarrhea

Semaglutide has oral versions (the Ozempic pill 1.5/4/9mg for type 2 diabetes, which reformulated and renamed Rybelsus in 2026, and the Wegovy pill 25mg for weight management) while tirzepatide is injection-only