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It should be used under medical supervision
1,6 Despite normal secretion of GLP-1 and GIP, the incretin effect is reduced or absent in people with type 2 diabetes, with the insulin-stimulating effect of GIP being more impaired when compared to GLP-1
This indicates that inter-individual variation in TL is established mainly early in life and that early life is an important stage in determining TL and may have a lasting effect on TL throughout the entire life course (Factor-Litvak and Susser, 2015)
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