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Cross-trial efficacy comparisons should be interpreted with caution given differences in study design, population, duration and primary endpoints
Keller et al., 2022), highlighting an opportunity to optimize intranasal formulations to effectively target the CNS
GLP-1s work on gut hormones and slow digestion, producing the highest average weight loss of any current option, often 15 to 20 percent or more of body weight
Modern devices often include safety features such as temperature monitoring, automatic shut-offs, and feedback control systems that can reduce the risk of thermal injury when properly utilized (Singh et al., 2022)
Over a year, that is $1,800 to $4,800, still substantial but far less than branded options
