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As expected, wild-type BoNT/X cleaved the VAMP1 fusion but showed no detectable activity on the procaspase-1 substrate (Extended Data Fig
& Schneich, C
Indigestion from GLP-1 injections , along with heartburn and general stomach discomfort, can be troublesome side effects of weight management and diabetes medications such as semaglutide (Wegovy) and tirzepatide (Mounjaro)
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Affected individuals have 5-oxoprolinuria, sometimes without symptoms and sometimes with relatively minor problems (eg, dusky episodes) (15)
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