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The regulatory read Randomized, double-blind, placebo-controlled Co-primary endpoints: PASI 75 + sPGA 0/1 at Week 16 (standard registration bar) Protocol aligned with both FDA and EMA de-risks a dual US/EU submission path Accrual continues toward ~705 total participants Read this as a milestone, not a signal

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Alternatively, if the elevated anion gap persists despite cessation of acetaminophen and administration of N-acetylcysteine, pyroglutamic acidosis is unlikely, and an alternative diagnosis should be sought