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A combination with GLP-1 receptor agonists is not recommended since DPP-4 inhibitors as well as GLP-1 receptor agonists elevate GLP-1 plasma concentrations

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Importantly, the largest reductions in BMI were observed in the southern United States, which also reported the highest rates of GLP-1 RA dispensing claims (Rader et al., 2024), a geographic concordance that is consistent with a causal contribution of these pharmacotherapies to the observed population-level BMI decline

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Ghisseli, A., Serafini, M., Natella, F