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What distinguishes Ipamorelin from other GHRPs (such as GHRP-6 or GHRP-2) is its exceptional selectivity : No significant cortisol increase: Unlike GHRP-6, Ipamorelin does not meaningfully elevate cortisol a stress hormone that can counteract GH benefits No prolactin stimulation: Elevated prolactin can interfere with reproductive hormones
Doherty TJ
IGFBP-3 (IGF binding protein 3)
Obesity is associated with many disorders such as type 2 diabetes (T2D), cardiovascular (CV) disease, fatty liver, osteoarthritis, and obstructive sleep apnea, etc
Adding cagrilintide to tirzepatide Theoretical protocol (not clinically studied): If on tirzepatide 10-15mg: Stable on tirzepatide for 4+ weeks Continue tirzepatide at current dose Add cagrilintide 0.6mg weekly Standard cagrilintide titration to 2.4mg Rationale: Tirzepatide is dual GIP/GLP-1 (very powerful alone) Adding amylin pathway could theoretically enhance No clinical data on this combination Uncertain if additional benefit over tirzepatide alone Concerns: GI side effects may be severe (both slow gastric emptying) Tirzepatide already produces 15-22% weight loss alone Unclear if cagrilintide adds meaningful benefit Expensive combination Verdict: Wait for clinical data
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