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The use of AI deep learning lesion classification confirmed this finding
Despite the enhanced HNE staining observed in our samples, we have to highlight on one hand that lipid peroxidation per se is not always recognized as relevant in APAP hepatotoxicity, and its contribution to liver injury after acetaminophen exposure is still debated 3,29,30,31,32
Opportunity exists for therapies with better tolerability profiles, though it may be difficult for an agent to achieve both enhanced efficacy and tolerability
Over time, these processes have led to the emergence of many superbugs. For example, surveillance data show that 42% of Escherichia coli isolates worldwide are resistant to third-generation cephalosporins and 15% of Staphylococcus aureus isolates are methicillin-resistant (MRSA) in elderly individuals
Cytokine 113 , 6873 (2019)
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