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For large quantity25 kg/fiber drum in net weight

3rd & Brookeman, J

Lastly, a high-fat diet supplemented with 10% guar gum over a duration of 12 weeks is introduced to C57B mice, resulting in the production of short-chain fatty acids through colonic fermentation that stimulate GLP-1 release, thereby enhancing glucose clearance [28]

The review would benefit from a bit more text on how this notion impacts the balance between desired therapeutic effects, "diluted" effects from dimer-mediated versus non-dimer effects, and undesired off-target effects (which are discussed some in terms of receptor specificity, but not in terms of anatomy, where the same dimer may have different effects in different brain regions). Response: We have added a new section title General treatment approaches before the concluding remarks

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