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The 'central planning' mechanism of GLP-1: from molecular signaling to systemic regulation GLP-1 is an incretin secreted by intestinal L cells, and its bioactive forms (GLP-1 (7-37) and GLP-1 (7-36) amide) have a half-life of only 2.1-2.4 minutes

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27,28 GLP-1 receptor agonists (GLP-1 RAs) have been developed for the treatment of metabolic disorders, including obesity and type 2 diabetes (T2D)

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