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Mutations in several genesincluding SOD1, TARDBP, FUS, UBQLN2, C9orf72, and TAF15have been found in approximately 5% of ALS cases

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Therefore, these could be considered a priori functional circuits of interest in studies of putative neuroinflammatory conditions such as ME/CFS

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Cefalu, W.T., et al., Efficacy and safety of canagliflozin versus glimepiride in patients with type 2 diabetes inadequately controlled with metformin (CANTATA-SU): 52 week results from a randomised, double-blind, phase 3 non-inferiority trial