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However, the addition of NAC or GSH induced the inhibition of these effects, suggesting that the modulation of antioxidant levels activated the endothelium [44]

In a recently published review, the advantages of eryptosis over hemolysis as a toxicological endpoint have been summarized, emphasizing that eryptosis in vitro testing has a higher sensitivity, is more accurate and reproducible, provides better quality control, and can shed light on the cytotoxicity-mediating molecular mechanisms compared with hemolysis [450]

Int J Nutr 134:489492 Xiao Z, La Fontaine S, Bush AI, Wedd AG (2019) Molecular mechanisms of glutaredoxin enzymes: versatile hubs for thiol-disulfide exchange between protein thiols and glutathione

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