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Geisler, J
Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agents
Blood chemistry panels showed no hepatotoxicity (ALT, AST, bilirubin all within normal limits), no nephrotoxicity (creatinine, BUN unchanged), and no hematologic changes
From a pharmacological safety perspective, the adverse effect profile of retatrutide based on Phase 1 and Phase 2 clinical trial data (including the NEJM 2023 Phase 2 trial) includes: Gastrointestinal effects: Nausea, vomiting, diarrhoea, and constipation (the most commonly reported side effects in trial participants) Injection site reactions: Redness, swelling, or discomfort at the injection site Cardiovascular effects: Increases in heart rate have been observed in trial participants [21] [22] Hypoglycaemia: Particularly relevant in individuals with diabetes or those taking insulin, sulfonylureas, or other glucose-lowering agents Potential thyroid effects: GLP-1 receptor agonists have been associated with thyroid C-cell changes in rodent studies
While B12 is not a cosmetic treatment, it plays a vital role in cellular energy, DNA repair, and nervous system health
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