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Unlike BCTC, exendin 939 also mitigated both thermal and mechanical nociceptive behaviors in mice without inducing hyperthermia, indicating that it is a viable analgesic without the common adverse effects associated with existing pain management strategies, such as opioids and traditional TRPV1 antagonists 32,42,51,52,53
doi: 10.2217/pgs.13.207, 107
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In addition, our findings demonstrate that m 6 A, the mRNA methylation modification mediated by methylases and demethylases, affects the maintenance of the ECSC state
On the other hand, patients with a history of frequent DKA, low body weight, or unstable glucose control may not be ideal candidates
