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By demonstrating protective effects in a ciliopathy model, this study suggests that GLP-1 RAs may confer benefits beyond appetite suppression in patients with genetic obesity syndromes affecting ciliary function, further broadening the mechanistic rationale for targeting this pathway across diverse genetic etiologies of obesity

Any preparation or administration of retatrutide must occur only within an approved clinical trial, carried out by trained healthcare personnel following the trial protocol

Women taking this medication may experience changes in their menstrual cycle or vaginal bleeding

But there are also important nuances to consider