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Further, a clinical trial of over 3,000 people living with type 2 diabetes and chronic kidney disease found that semaglutide led to improvement for kidney, cardiovascular, and survival outcomes including a 24% reduced risk of kidney disease events and18% lower risk of major cardiovascular events compared to placebo

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This suppression is independent of plasma cholesterol changes and BW reduction through regulating markers of plaque instability and inflammation including those linked to plaque hemorrhage (CD163), matrix turnover (matrix metalloproteinase (MMP)-3, MMP-13), cholesterol metabolism (prostaglandin I2 synthase (PTGIS), ATP-binding cassette transporter 1 (ABCA1)), leukocyte recruitment (C-C motif chemokine ligand 2 (CCL2), osteopontin (OPN), interleukin (IL)-6), and leukocyte rolling, extravasation and adhesion (vascular cell adhesion molecule (VCAM)-1, E-selectin (SELE)) [16]

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PMID 40005999