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The excellent clinical manifestations of Tan IIA provide supportive evidence for targeting the GSH system in the treatment of heart diseases, which may be promising for transforming natural compounds from basic research to clinical applications

It is combined with arginine to improve oral bioavailability and resist breakdown by stomach acid

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It transports nutrients to dysfunctional potassium channels and helps to restore functionality

Spermidine attenuates bleomycin-induced lung fibrosis by inducing autophagy and inhibiting endoplasmic reticulum stress (ERS)-induced cell death in mice