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Semaglutide is sold under three brand names, each with slightly different dosing profiles: Ozempic injectable, once-weekly, approved for type 2 diabetes and cardiovascular risk reduction Wegovy injectable, once-weekly, higher dose (up to 2.4 mg), approved for weight management Rybelsus oral tablet, taken daily, approved for type 2 diabetes All three share the same active ingredient and similar side-effect profiles, though Wegovy at higher doses tends to cause more frequent GI symptoms
Transdermal systems may: Provide a needle-free alternative Be easier to use for those with needle aversion Potentially maintain more stable drug levels over time However, it's important to note that the effectiveness and safety of GLP-1 patches have not yet been evaluated in human clinical trials
Mar 16 2021;51(2):131-148
