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doi: 10.3389/fnut.2022.853058 Received 12 January 2022 Accepted 11 February 2022 Published 14 March 2022 Volume 9 - 2022 Edited by Anna Maria Giudetti, University of Salento, Italy Reviewed by Stefan Kabisch, Charit Universittsmedizin Berlin, Germany

Strengths: No needles Higher bioavailability than oral spray for some peptide sequences Convenient, discreet administration Does not require first-pass metabolism considerations Considerations: Patient technique still matters Nasal irritation in some patients Seasonal nasal congestion can affect absorption Sublingual: A Close Cousin to Oral Spray Sublingual delivery places the peptide under the tongue for mucosal absorption

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Delayed orthostatic hypotension: a frequent cause of orthostatic intolerance

Without an insulin comparison, a selective inhibitor or a null background, an effect measured after adding this protein cannot be assigned cleanly to IGF-1R as opposed to the insulin receptor or to hybrid receptors