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Reported Effects Synaptogenesis (in-vitro): Increased dendritic-spine formation in cultured hippocampal neurons the origin of the ~10-million BDNF ratio, now low-confidence because the source papers were retracted [4]

Unlike GLP-1 agonists, the changes are compositional rather than scale-weight driven: patients may not lose significant total body weight but will show meaningful reduction in waist circumference and visceral fat volume

This is noteworthy as (1) many biologically active peptides contain an -helix (a large fraction of PPIs involve an -helix) and (2) those helix portions could potentially be replaced or partially replaced by oligoureas with minimal effect on the binding while improving the proteolytic resistance of the peptide

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