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Lustig RH: The neuroendocrine regulation of energy balance

Loss of potency from degradation is not always obvious to the naked eye, which is why respecting the 28-day window is critical

Along with the duodenum, GLP-1 agonists arise naturally in the brain, lungs and musculoskeletal system, as well as the pancreas and the kidney

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[1] While this is usually not clinically significant for most medications, it's worth noting, particularly when initiating treatment