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Martchenko A, Oh RH, Wheeler SE, Gurges P, Chalmers JA, Brubaker PL

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Efforts to improve potency while retaining the optimal profile led to the most balanced Compound 77 , which combines a methyl-pyridine and methyl-1,3,4-thiadiazole motif, achieving high potency, selectivity, and favorable PK, making it a lead candidate for further evaluation

doi:10.1038/s41598-022-19634-2 (PMID 36104373) U.S