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A crucial role of lactate accumulation in cancer cells has been demonstrated regarding its ability to induce expression of anti-inflammatory and proangiogenic genes, together with the modification of histones through a process called lactylation, where a lactyl-CoA is added to lysine residues present in the tails of histones [33]

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Antioxid Redox Signal 2020;32:123942

Additionally, the ethical landscape of off-label prescribing is continuously evolving, with new research findings emerging regularly