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2a), increased the plasma GLP-1 and insulin levels, decreased the blood glucose levels, as well as improved the oral glucose tolerance in TR flox/flox (Floxed) mice (Fig

Clinical data shows weight regain of 20-50% of lost weight within months after cold-turkey cessation

The researchers tracked changes in heart rate from baseline over 48 weeks

The study authors found that nearly 65% of study subjects who were taking the medications explicitly for weight loss, rather than diabetes control, ended up going off them within a year