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c , Immunoblot of indicated proteins in HEK-293T (top) and K562 (bottom) cells treated with BSO (1 mM;10 M, respectively) for the indicated days
Gln is metabolized by GLS to produce alpha-ketoglutaric acid (-KG), which serves as a crucial cofactor for TET enzymes that catalyze DNA demethylation, as well as for histone demethylases like JHDM
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