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Because of strong evidence for such side-effects, they are described in patient leaflets as very common although manufacturers note they usually go away over time

The risk is not only the sequence Even where a molecule is biologically plausible, the product introduces a second layer of risk such as sterility and endotoxin contamination, incorrect peptide identity or concentration, degradation during storage, aggregation and immunogenicity, synthesis-related impurities, injection-site infection or granuloma, unpredictable systemic exposure and an absence of long-term carcinogenicity and reproductive data

Clinical studies show that consistent collagen intake can reduce wrinkle depth and roughness, especially around the eyes and mouth, where signs of aging appear first

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