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Safety Assurance: The complication coefficient is close to zero when working with original vial formulations in licensed polyclinic environments approved by the Ministry
The possible reasons include the reduction of Hcy metabolizing enzyme activity, the impairment of renal function, hormonal changes, and the reduction of vitamin B12/B6 level as cofactor (34)
Commonly reported side effects include injection-site irritation, headache, fatigue, and mild gastrointestinal discomfort
population was at risk for anemia (low red blood cells or hemoglobin, often caused by iron deficiency) or at least one vitamin deficiency---meaning they fell below the deficiency cutoffs established from CDC data for at least one micronutrient
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