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The International Working Group defines Alzheimers disease as a clinical-biological entity requiring both the presence of positive pathophysiological biomarkers (A and tau) and a specific clinical phenotype consistent with Alzheimers disease that commonly include amnestic syndrome of the hippocampal type, logopenic aphasia, and posterior cortical atrophy or, less commonly, corticobasal syndrome and behavioral and dysexecutive variants

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