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However, STEP 1 extension concluded that 1-year withdrawal of semaglutide results in regain of two-thirds of prior weight loss [97], highlighting that withdrawal of semaglutide results in weight regain which may be problematic in older adults who are already using polypharmacy approaches for comorbid disease
doi: 10.1016/j.clim.2020.108544 29 JainS
In this context, therapies such as GLP-1RAs may represent a complementary strategy aimed at modulating both metabolic dysfunction and inflammation, thereby optimizing disease control and improving long-term outcomes in PsA
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