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We demonstrated that the GSH synthesis inhibitor buthionine sulfoximine (BSO) synergistically enhanced L-PAM activity (inducing 24 logs of cell kill) against nine MM cell lines (also in the presence of marrow stroma or cytokines) and in seven primary MM samples (combination indices 100 days, and significantly increased the median event-free survival relative to L-PAM alone
Set realistic expectations - most people notice initial improvements around 2-4 weeks, with significant brightening effects appearing after 6-8 weeks of consistent use
however, use should be discouraged until these are validated [100]
Clinical and Translational Gastroenterology, 14(4), e00567
39,40,43 There may be several possible explanations for the failure of GLP-1 RAs in HFrEF studies
