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Why this matters for prescriptions and insurance Insurance coverage, prior authorization criteria, and manufacturer savings programs typically operate at the product-label and indication level, not just the molecule level
Abbreviations ADA: American Diabetes Association ARR: Absolute risk reduction BW: Body weight CI: Confidence interval CKD: Chronic kidney disease CV: Cardiovascular CVD: Cardiovascular disease CVOT: Cardiovascular outcomes trial EASD: European Association for the Study of Diabetes eGFR: Estimated glomerular filtration rate GI: Gastrointestinal GLP-1RA: Glucagon-like peptide-1 receptor agonist HbA 1c : Glycated haemoglobin HR: Hazard ratio KDIGO: Kidney Disease:Improving Global Outcomes ln : Natural logarithm MACE: Major adverse cardiovascular event OD: Once-daily OW: Once-weekly P1: First percentile P99: 99th percentile p INT : Interaction p value Q1: First quartile Q3: Third quartile SAE: Serious adverse event s.c.: Subcutaneous SGLT2i: Sodiumglucose cotransporter-2 inhibitor T2D: Type 2 diabetes UACR: Urine albumin:creatinine ratio References Trujillo JM, Nuffer W, Smith BA
Semaglutide is injected under the skin (subcutaneously) once a week, on the same day each week
These are not medical prescriptions
Clinical trials have demonstrated substantial weight losswith SURMOUNT obesity trials showing 1522% of body weight reduction at higher doses, while more modest losses were observed in type 2 diabetes trials
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