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We monitor and adjust dosing to minimize side effects
Healthcare professionals should be aware that patients may be using berberine products without disclosure
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Reduced endothelial activation and leukocyte adhesion are particularly relevant to early vascular dysfunction
Full publication of combination-therapy data is awaited, however interim analysis from the phase II COURAGE trial (NCT06299098) found 3.3% reduction in lean mass of obese patients treated with the combination of trevogrumab and semaglutide, compared with 6.5% reduction with semaglutide alone [70]
