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Landmark trials like STEP 1 and STEP 2 used a 4-week escalation schedule (0.25 mg 0.5 mg 1.0 mg 1.7 or 2.4 mg) and demonstrated both safety and significant weight loss
The patients had a mean age of 65 years old, 84.2% were men and the mean BMI was 31.9 kg/m 2
These effects are statistically significant but clinically modest
Clinical studies show that most patients lose between 510% of baseline body weight within 12 weeks, though some notice changes as early as week one
These pathways play a role in appetite, fullness, digestion, food intake, and metabolic signaling
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