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In the next few months, the EVOKE trials will show the cleanest readout yet on whether GLP-1s can slow Alzheimer's disease
Hes giving instructions for people on the forum for how to try these things themselves
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A key challenge in studying native GLP-1 is its extremely short in vivo half-life of approximately 12 minutes, owing to rapid inactivation by dipeptidyl peptidase-4 (DPP-4), which cleaves the N-terminal His-Ala dipeptide from GLP-1 to produce the inactive metabolite GLP-1(936)amide
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