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Interestingly, the closest relatives of many mtDNA-modifying enzymes, such as mtDNA polymerase, are bacteriophage proteins [94], suggesting that an infection of the mitochondrial ancestor contributed to the development of mtDNA maintenance machinery

The inhibitory ability of the designed peptide (CAND) was then verified using FPA competition analysis to ensure its continued effectiveness in inhibiting the interaction between FOXO4 and p53 TAD (Figure

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