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Any effective patch must use advanced technologies such as microneedles or specialized carriers to get the drug into the body

As the mitochondria become damaged, they leak their contents into the cellular cytoplasm, which the immune system recognizes as a danger signal, further amplifying the inflammatory response in a vicious, self-perpetuating cycle

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Furthermore, NO can also nitrosylate specific proteins within the endoplasmic reticulum, resulting in the accumulation of misfolded proteins, ER stress and subsequent NOX activation (216)

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