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Given that GLP-1 biology is complex and may involve several parallel mechanisms with or without transmembrane receptors (31) and distinct metabolites (32), we chose to next focus on the direct actions of the single metabolite GLP-1(2836) using in-depth in vitro studies into its cellular and molecular actions
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To study systemic distribution of the GLP-1 albumin fusions following SC administration, we measured the presence of the proteins in the blood for up to 12 days post-injection into the scruff of the neck of human FcRn Tg32 mice (Fig
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