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This single-school concentration is one of the most important caveats to keep in mind throughout the rest of this article, and it is the reason the field is best described as under-replicated rather than either proven or debunked. Cytamins Versus Cytogens: From Tissue Extracts to Designed Peptides Because the two-generation distinction is so central, it is worth examining more closely how the field moved from crude extracts to defined sequences, and what that transition did and did not resolve