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Semaglutide is contraindicated in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2, and is not recommended during pregnancy or breastfeeding
The closest human data comes from CB4211, a MOTS-c analog tested in a Phase 1a/1b study
2021;131(20):e151800.
2004;65 Suppl 3:38-45
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