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Barkmeier and colleagues compared the effect of multiple antihyperglycemic agentsnamely SGLT-2I, dipeptidyl peptidase-4 (DPP-4), GLP-1RA, and sulfonylureason the need for treatment of diabetic macular edema or PDR in a cohort of 371,698 patients using US claims data
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But why dont these drugs work
Limited to in vitro testing and laboratory experimentation
The Endocrine Society's guideline on obesity pharmacotherapy includes the recommendation that "clinicians should counsel patients that responses to anti-obesity medications vary, and that expectations should be guided by clinical trial data, not anecdotal reports" 7
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