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GLP-1 receptor agonists suppress appetite and improve satiety through central nervous system pathways, so an abrupt stop removes that signal quickly and overwhelms the body's compensatory hunger mechanisms

First identified nearly 50 years ago, scientists have since uncovered the crucial role this hormone plays in type 2 diabetes, where levels are often lower or the bodys response to it is impaired

More serious but rare side effects include: Pancreatitis (inflammation of the pancreas) Gallbladder problems Changes in heart rate While these serious complications are uncommon, they underscore why these drugs require medical supervision

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Highlights of Prescribing Information: Xenical (orlistat) capsules, for oral use