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During the production of ATP, the transport of electrons generates reactive oxygen species (ROS) that damage macromolecules, such as mitochondrial DNA, proteins and lipids
Melanin synthesis resumes at the natural rate determined by UV exposure and genetic baseline, but without the compensatory MITF upregulation that drives hydroquinone rebound
Safety, tolerability and efficacy of up-titration of guideline-directed medical therapies for acute heart failure (STRONG-HF): a multinational, open-label, randomised, trial
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