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In Figure12, the black curves show the GSH concentration in the liver (Panel A) and the fraction of functional hepatocytes as a function of time (Panel B) after a 22 g dose of APAP

Examples: For a GFR change of 150 to 100 (50 % change), the creatinine increases from about 0.45 to 0.90 mg/dL (100 % change)

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Effects on paracetamol-induced cytotoxicity, lipid peroxidation and glutathione depletion in rat hepatocytes - Biochem Pharmacol - 1990 Jun 15