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Importantly, no participants experienced clinically significant hypoglycemia, medullary thyroid cancer, or C-cell hyperplasia, consistent with the known safety profile of incretin therapies
Much like other injections such as Mounjaro and Nevolat, Wegovy follows a recommended dosage schedule that gradually increases in strength until it reaches the maximum maintenance dose
The theory is that periodic carbohydrate refeeds support thyroid function, replenish muscle glycogen for intense training, and provide psychological relief from strict restriction
NICE technology appraisal guidance (TA875) recommends semaglutide 2.4mg for adults with a BMI of 35 kg/m or greater, or 30 kg/m or greater with at least one weight-related comorbidity, when provided alongside a reduced-calorie diet and increased physical activity