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Bit of Background These new classes of antiobesity medications (ie, the GLP-1 agonists and dual agonists), referred to in this article as weight management medications, arent really new.1-4 The basic science and pharmaceutical research and development to bring these to market began more than two decades ago when two scientists, Matthias Tschop, MD, and Richard DiMarchi, PhD, hypothesized that the actions of various gut hormones may offer safe and unprecedented weight loss
Meanwhile, Christian de Duves group and Earl Sutherland et al localised the secretory origin of glucagon to the pancreatic alpha cells and also identified the gastric mucosa as a source of glucagon [8, 9]
10.1038/nrd.2015.6 Nat
Time is the variable that separates reversible organ stress from permanent damage
The key is to cite the primary papers
