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But the alternative chemical synthesis is not easy at scale
10.1016/S0378-5173(98)00212-9 242 PerkinsG
The differences usually come from what is counted as part of the market, the year selected for the base, and how pricing and adoption are assumed to move over time
Initial studies demonstrated that although mature erythrocytes contain procaspase-3 and procaspase-8, they are devoid of the mitochondrial apoptotic machinery, e.g., APAF-1, cytochrome c, and caspases-2, -6, -7, and -9 [22, 23]
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