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the human evidence is at the level of outcomes (people ate less and lost weight), not mechanism
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Because they work through entirely different biological pathways, there is no mechanism conflict between the two therapies
For example, in ovarian cancer, a mutation in the p53 gene was seen in platinum chemotherapy [131] and, in BC treated with anticancer drugs, reduced response to chemotherapy
However, they work through different receptor systems and have different drug profiles
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