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A medicine supply notification issued by the Department of Health and Social Care on 27 June 2023 said the high impact shortage has been caused by an increase in demand for these products for licensed and off-label indications, with supply not expected to return to normal until at least mid-2024

Leading obesity medicine societies now classify obesity as a chronic disease, and GLP-1 treatment as potentially long-term management, similar to statins for cholesterol or antihypertensives for blood pressure

Fat can also build up in the blood vessels, which can increase the risk of heart attack or stroke

The most effective time of day for administration is typically first thing in the morning, immediately upon waking

Eur J Heart Fail 22:19841986 Mizuno Y, Harada E, Nakagawa H, Morikawa Y, Shono M, Kugimiya F, Yoshimura M, Yasue H (2017) The diabetic heart utilizes ketone bodies as an energy source