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This phenomenon is clearly observed in the STEP 2 trial of semaglutide (2.4 mg weekly), where a cumulative 33.7% of patients with obesity and T2D reported nausea throughout the duration of the trial (20)
The most commonly reported Retatrutide side effects in clinical research have been gastrointestinal, especially nausea, diarrhea, vomiting, and constipation
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We previously showed that GIPR activity in alpha cells potentiates amino-acid-stimulated glucagon secretion in mouse islets 11 , and here we found the same interaction between hGIP and amino acids in human islets using concentrations of amino acids found in the postprandial state (Extended Data Figure 4) 11 , prompting us to ask whether tirzepatide engagement of the GIPR in human islets also enhances the effect of amino acids on glucagon secretion
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