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In the second reaction, glycine is attached to the C-terminal of -EC and this reaction is catalyzed by glutathione synthase (GSH2, EC 6.3.2.3) forming the tripeptide reduced glutathione (GSH) (Meister 1988) (Figure 4.1)
The generally low GLP-1R expression suggests it is unlikely to play a major role in cancer development or progression
Sermorelin has prior FDA approval history
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Cysteine oxidation takes a different form
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